Catherijne A J Knibbe Selected Research

Midazolam (Versed)

10/2021	Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis.
1/2021	Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study.
1/2021	The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study.
1/2018	Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.
1/2018	Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults.
1/2016	Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children.
11/2015	Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.
8/2012	Critical illness is a major determinant of midazolam clearance in children aged 1 month to 17 years.

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Catherijne A J Knibbe Research Topics

Disease

27	Body Weight (Weight, Body) 01/2022 - 06/2005
20	Obesity 01/2022 - 05/2012
17	Pain (Aches) 01/2022 - 12/2011
15	Critical Illness (Critically Ill) 10/2021 - 12/2002
8	Birth Weight (Birth Weights) 01/2022 - 01/2009
7	Morbid Obesity 01/2022 - 08/2009
5	Postoperative Pain 01/2022 - 11/2014
5	Infections 01/2022 - 11/2014
5	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2019 - 02/2009
4	Inflammation (Inflammations) 01/2018 - 08/2012
3	Patent Ductus Arteriosus 01/2022 - 12/2018
3	Mycoses (Diseases, Fungus) 01/2022 - 01/2019
3	Chronic Pain 01/2019 - 01/2016
3	Insulin Resistance 02/2017 - 04/2014
2	Cholecystitis 01/2022 - 01/2017
2	Down Syndrome (Down's Syndrome) 01/2021 - 10/2016
2	Apnea 01/2021 - 01/2021
2	Sepsis (Septicemia) 10/2019 - 12/2017
2	Overweight 08/2018 - 11/2015
2	Hypothermia 04/2018 - 12/2017
2	Disease Progression 11/2017 - 11/2017
2	Neoplasm Metastasis (Metastasis) 12/2007 - 12/2004
1	Frailty 01/2022
1	Invasive Candidiasis 01/2022
1	Candidiasis (Moniliasis) 01/2022
1	Breakthrough Pain 12/2021
1	Congenital Diaphragmatic Hernias 10/2020
1	Esophageal Atresia 10/2020
1	Gastroesophageal Reflux (GERD) 10/2020
1	Aspergillosis 05/2020
1	Asthma (Bronchial Asthma) 01/2020
1	Invasive Fungal Infections 01/2020
1	Malaria 01/2020
1	Status Asthmaticus 01/2020
1	COVID-19 01/2020
1	Pneumonia (Pneumonitis) 01/2020
1	Poisoning 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Drug-Related Side Effects and Adverse Reactions 01/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 12/2019

Drug/Important Bio-Agent (IBA)

25	Pharmaceutical PreparationsIBA 01/2022 - 06/2005
10	Morphine (MS Contin)FDA LinkGeneric 01/2022 - 01/2013
9	Propofol (Diprivan)FDA LinkGeneric 01/2019 - 12/2002
8	Midazolam (Versed)FDA LinkGeneric 10/2021 - 08/2012
7	Analgesics (Analgesic Drugs)IBA 12/2021 - 01/2013
7	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2021 - 01/2013
5	Remifentanil (Ultiva)FDA Link 01/2019 - 11/2014
4	Ibuprofen (Motrin)FDA LinkGeneric 01/2022 - 02/2012
4	Opioid Analgesics (Opioids)IBA 01/2022 - 01/2016
4	Gentamicins (Gentamicin)FDA LinkGeneric 11/2020 - 07/2015
4	Cytochrome P-450 CYP3AIBA 01/2018 - 08/2012
4	Biomarkers (Surrogate Marker)IBA 11/2017 - 06/2012
3	Fentanyl (Sublimaze)FDA LinkGeneric 01/2022 - 11/2014
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2021 - 03/2014
3	Vancomycin FDA LinkGeneric 11/2021 - 11/2014
3	Hypnotics and Sedatives (Sedatives)IBA 10/2021 - 11/2015
3	AminoglycosidesIBA 10/2019 - 12/2017
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2018 - 10/2014
3	Busulfan (Busulfex)FDA Link 10/2012 - 02/2009
3	Melphalan (Alkeran)FDA LinkGeneric 02/2009 - 12/2004
2	Fluconazole (Zonal)FDA LinkGeneric 01/2022 - 01/2022
2	Cefazolin (Ancef)FDA LinkGeneric 01/2022 - 03/2014
2	CreatinineIBA 01/2022 - 11/2021
2	Doxapram (Doxapram Hydrochloride)FDA LinkGeneric 01/2021 - 01/2020
2	TabletsIBA 05/2020 - 01/2020
2	posaconazole FDA Link 05/2020 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 08/2018 - 04/2014
2	Metformin (Glucophage)FDA LinkGeneric 08/2018 - 06/2014
2	C-Reactive ProteinIBA 01/2018 - 01/2016
2	Amikacin (A.M.K)FDA LinkGeneric 12/2017 - 02/2012
2	thymoglobulin FDA Link 04/2017 - 04/2015
2	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 04/2017 - 05/2015
2	Nadroparin (Nadroparin Calcium)IBA 01/2015 - 02/2012
2	Phenobarbital (Luminal)FDA Link 06/2014 - 01/2013
1	Ciprofloxacin (Cipro)FDA LinkGeneric 01/2022
1	FluoroquinolonesIBA 01/2022
1	Amoxicillin (Wymox)FDA LinkGeneric 01/2021
1	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 01/2021
1	Caffeine (No Doz)FDA LinkGeneric 01/2021
1	Omeprazole (Prilosec)FDA LinkGeneric 10/2020
1	Antimalarials (Antimalarial Agents)IBA 01/2020
1	Albuterol (Salbutamol)FDA LinkGeneric 01/2020
1	Chloroquine (Aralen)FDA LinkGeneric 01/2020
1	TriazolesIBA 01/2020
1	SirtuinsIBA 12/2019
1	Alemtuzumab (Campath)FDA Link 12/2019

Therapy/Procedure

8	Therapeutics 01/2022 - 08/2009
4	Cell Transplantation 12/2019 - 04/2015
3	Bariatric Surgery 01/2020 - 01/2011
3	Drug Therapy (Chemotherapy) 01/2020 - 01/2017
2	Cholecystectomy 01/2022 - 01/2017
2	Antibiotic Prophylaxis 01/2022 - 01/2017
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2021 - 10/2016
2	Extracorporeal Membrane Oxygenation 01/2020 - 04/2018
2	Critical Care (Surgical Intensive Care) 10/2016 - 11/2015
2	Metastasectomy 12/2007 - 12/2004
1	Polypharmacy 01/2022
1	Intravenous Administration 01/2022
1	Vascular Access Devices (Arterial Line) 01/2021